C;B6CB-Tnf<tm1Sek>
C;B6CB-Tnf<tm1Sek>
C（3〜6か月）
1997年 家畜衛生試験場 関川賢二先生らにより開発。 TT2 ES細胞由来。東大医科研岩倉研でBALB/cAに8世代戻し交配 (兄妹交配7代) (BRC寄託時)。 (C57BL/6 × CBA) F1 (TT2)
Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol>
TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Lab. Invest., 77, 647-658 (1997).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature designated by the DEPOSITOR is requested.
<a href='https://brc.riken.jp/mus/pcr05119'>Genotyping protocol -PCR-</a>
BALB/cAJcl
mouse tnf genomic DNA, Neomycin resistance gene (E. coli), Phosphoglycerate kinase (PGK) promoter (mouse)
RBRC05119
TNF alpha knockout mice. Homozygous mutant mice show increased susceptibility to infection.
Immunology and Inflammation Research
C (3-6 months)
covid19_onset
true
Yoichiro IWAKURA
1997年 家畜衛生試験場 関川賢二先生らにより開発。TT2 ES細胞由来。東大医科研岩倉研でBALB/cAに8世代戻し交配 (兄妹交配7代) (BRC寄託時)。(C57BL/6 × CBA) F1 (TT2)
岩倉 洋一郎
TNF alpha遺伝子欠損マウス。細菌等に対して易感染性。
Developed by Kenji Sekikawa, STAFF-Institute in 1997. The mice were backcrossed to BALB/c for at least 12 times by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo.
条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Lab. Invest., 77, 647-658 (1997).<br>研究成果の公表にあたって謝辞の表明を必要とする。研究成果の公表にあたって寄託者の指定する文献を引用する。
BALB-Tnf KO